BICD1抗体;BICD1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12947(BICD1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The BICD1 (Bicaudal D Homolog 1) antibody is a tool used to detect and study the BICD1 protein, a member of the Bicaudal D family involved in intracellular transport processes. BICD1 functions as an adaptor protein, linking cytoplasmic dynein motor complexes to various cargoes (e.g., vesicles, organelles) for microtubule-dependent transport. It plays critical roles in maintaining Golgi apparatus organization, neuronal transport, and nuclear positioning during cell division. Dysregulation of BICD1 has been implicated in diseases, including neurodevelopmental disorders and cancers.

BICD1 antibodies are widely used in research to investigate protein localization, expression levels, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These antibodies help elucidate BICD1's role in cellular dynamics, particularly in neurons where retrograde transport is vital. Commercial BICD1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions). Validation includes testing for specificity in knockout cell lines or tissues.

Recent studies highlight BICD1's potential as a biomarker in certain cancers, emphasizing the antibody's diagnostic and therapeutic relevance. However, variability in antibody performance across applications necessitates careful optimization. Overall, BICD1 antibodies remain essential for advancing understanding of intracellular trafficking mechanisms and disease pathology.