USP37抗体;USP37 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12926(USP37 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12926(USP37 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The USP37 antibody is a research tool designed to detect and study ubiquitin-specific protease 37 (USP37), a deubiquitinating enzyme (DUB) belonging to the ubiquitin-specific protease family. USP37 plays a critical role in regulating the cell cycle, DNA replication, and genome stability by removing ubiquitin chains from specific substrates. It is known to interact with key cell cycle regulators, such as Cyclin A and Cdt1. influencing their stability and activity during S phase and mitotic progression. USP37 also participates in the DNA damage response and has been implicated in cancer due to its overexpression in certain malignancies, where it may promote tumor growth by stabilizing oncoproteins like c-Myc.

Antibodies targeting USP37 are widely used in molecular biology to investigate its expression levels, subcellular localization, and protein-protein interactions in various cellular contexts. These antibodies enable techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding in the exploration of USP37’s functional mechanisms and its role in diseases. Research using USP37 antibodies has contributed to understanding how dysregulation of DUBs impacts cellular homeostasis and disease pathways, highlighting USP37 as a potential therapeutic target in oncology.