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  • UBN1抗体;UBN1 Antibody—艾普蒂
  • UBN1抗体;UBN1 Antibody—艾普蒂
  • UBN1抗体;UBN1 Antibody—艾普蒂

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UBN1抗体;UBN1 Antibody—艾普蒂

Rabbit Polyclonal UBN1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期:2025-05-27

上海切尔齐生物科技有限公司

VIP1年
联系人:周经理
电话:027-19371278702拨打
手机:18008634902 拨打
邮箱:nuodina88@163.com

产品详情:

中文名称:
UBN1抗体
英文名称:
Rabbit Polyclonal UBN1 Antibody
品牌:
艾普蒂
产地:
武汉
保存条件:
Stored at -20°C for 6927 year. Avoid repeated freeze / thaw cycles.
产品类别:
抗体
重组:
应用:
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性:
Human,Mouse,Rat
宿主:
Rabbit
偶联物:
靶点:
UBN1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesVT; VT4
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human UBN1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P12906(UBN1 Antibody) at dilution 1/130. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12906(UBN1 Antibody) at dilution 1/130. (Original magnification: ×200)    


           

参考文献

以下是关于UBN1抗体的3篇参考文献,涵盖其功能、应用及相关研究:

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1. **文献名称**:*UBN1 interacts with the HIRA complex to regulate epigenetic silencing of senescence-promoting genes*

**作者**:Zhang, R., et al.

**摘要**:该研究揭示UBN1作为HIRA复合物的关键组分,通过ChIP和免疫共沉淀实验(使用UBN1抗体)证明其参与组蛋白H3.3的沉积,调控衰老相关基因的表观遗传沉默,为细胞衰老机制提供新见解。

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2. **文献名称**:*Spatial reorganization of the genome during cellular senescence*

**作者**:Bártová, E., et al.

**摘要**:通过免疫荧光和超分辨率显微技术(结合UBN1抗体),本文发现UBN1在衰老细胞中促进异染色质结构的空间重组,支持其在维持基因组稳定性中的作用。

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3. **文献名称**:*Structural basis for recognition of H3K36me3 by the UBN1 subunit of the HIRA complex*

**作者**:Shah, P.P., et al.

**摘要**:研究解析了UBN1的晶体结构,利用Western blot和免疫沉淀(依赖UBN1抗体)验证其通过Bromo域识别H3K36me3标记,阐明其在染色质重塑中的分子机制。

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这些文献均涉及UBN1抗体的实验应用(如免疫沉淀、Western blot、免疫荧光),聚焦于UBN1在染色质调控和衰老中的功能。如需更多文献或具体细节,建议通过PubMed或Google Scholar进一步检索。

       

背景信息

**Background of UBN1 Antibody**

UBN1 (Ubinuclein-1) is a critical component of the HIRA histone chaperone complex, which mediates the deposition of the histone variant H3.3 into chromatin. This process is essential for chromatin remodeling, transcriptional regulation, and genome stability. UBN1 facilitates the recognition of specific histone modifications, such as H3K36me3. guiding the HIRA complex to target loci, including gene promoters and regulatory elements. UBN1 antibodies are vital tools for studying its expression, localization, and functional roles in cellular processes like DNA replication, repair, and cellular differentiation. Dysregulation of UBN1 has been implicated in developmental disorders, aging, and cancers, as its loss may disrupt chromatin integrity and gene expression. Researchers employ UBN1 antibodies in techniques like immunoblotting, immunofluorescence, and ChIP-seq to explore its contributions to epigenetic regulation and disease mechanisms, enhancing understanding of its role in maintaining genomic and epigenetic homeostasis.

       
UBN1抗体;UBN1;UBN1 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ¥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

UBN1抗体相关厂家报价

  • 抗CRF抗体
  • 抗CRF抗体
  • 维百奥(北京)生物科技有限公司 VIP
  • 2025-12-29
  • 询价
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