UBA52抗体;UBA52 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12903(UBA52 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12903(UBA52 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

**Background of UBA52 Antibody**

UBA52. a ubiquitin-ribosomal fusion protein, encodes ubiquitin and the 60S ribosomal protein L40. Ubiquitin is a highly conserved regulatory protein critical for protein degradation via the ubiquitin-proteasome system (UPS), which governs cellular processes like cell cycle progression, DNA repair, and stress response. The UBA52 gene produces a precursor protein that is post-translationally processed to release ubiquitin and the functional ribosomal protein L40. This unique fusion mechanism ensures coordinated synthesis of ubiquitin and ribosomal components, linking protein turnover and ribosome biogenesis.

Antibodies targeting UBA52 are essential tools for studying its dual role in ubiquitin-dependent pathways and ribosome assembly. They help detect UBA52 expression levels, localization, and processing in various tissues or experimental models. Research applications include investigating dysregulation in cancers, neurodegenerative diseases, or conditions linked to UPS dysfunction. Such antibodies are often validated in techniques like Western blotting, immunohistochemistry, and immunofluorescence.

Understanding UBA52’s biology through specific antibodies provides insights into cellular homeostasis, disease mechanisms, and potential therapeutic targets modulating ubiquitin or ribosomal pathways. Its conservation across species also makes it a valuable marker in comparative studies.