IWS1抗体;IWS1 Antibody—艾普蒂

The IWS1 (Interacts with Spt6) antibody is a research tool used to study the IWS1 protein, a key regulator of transcriptional elongation and chromatin modification. IWS1 interacts with the transcription elongation factor Spt6 and RNA polymerase II, facilitating the recruitment of histone methyltransferases like SetD2 to promote H3K36me3 deposition, a mark associated with active transcription. This protein also plays a role in coupling transcription with mRNA export and surveillance. Dysregulation of IWS1 has been implicated in cancers, including leukemia and solid tumors, due to its influence on oncogenic gene expression programs. The antibody is commonly employed in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate IWS1's expression, localization, and interactions in cellular models. Studies using IWS1 antibodies have highlighted its phosphorylation-dependent regulation, particularly during cellular stress responses. Its role in epigenetic regulation and disease pathways makes it a focus in cancer biology and transcriptional research.