VCX抗体;VCX Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12894(VCX Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12894(VCX Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

VCX antibodies target proteins encoded by the Variable Charge, X-linked (VCX) gene family, which includes VCX, VCX2. VCX3A, and VCX3B. These genes are located on the X chromosome and are characterized by tandemly arranged, highly homologous sequences. VCX proteins are small, positively charged molecules primarily expressed in male germ cells during spermatogenesis, suggesting a role in sperm development and function. Their variable charge properties are attributed to repetitive amino acid motifs, which may influence interactions with nucleic acids or other cellular components.

The VCX gene family has garnered interest due to its involvement in X-linked intellectual disability (XLID) syndromes. Mutations or deletions in VCX genes, particularly VCX3A, have been linked to neurodevelopmental disorders, though the exact mechanisms remain unclear. VCX antibodies are essential tools for studying these proteins' expression patterns, subcellular localization, and functional roles in both reproductive and neurological contexts.

In research, VCX antibodies are employed in techniques like immunohistochemistry, Western blotting, and immunofluorescence to explore protein expression in tissues, notably the testis and brain. They also aid in investigating potential cross-talk between VCX proteins and other cellular pathways, including epigenetic regulation. Despite their specialized focus, VCX antibodies contribute broadly to understanding human fertility, genetic diseases, and X-chromosome biology.