WDR11抗体;WDR11 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P12875(WDR11 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 50 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12875(WDR11 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12875(WDR11 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The WDR11 antibody is a research tool designed to detect the WDR11 (WD repeat-containing protein 11) protein, a member of the WD-repeat protein family characterized by conserved structural motifs involved in protein-protein interactions. WDR11 plays critical roles in ciliogenesis, Hedgehog signaling, and neuronal development, with genetic links to Kallmann syndrome (a disorder combining hypogonadism and anosmia) and congenital hypogonadotropic hypogonadism. It interacts with key regulators like EMX1 and USP7. influencing transcription, cell cycle progression, and post-translational modifications. Dysregulation of WDR11 is also implicated in cancers, including prostate and breast cancer.

Antibodies targeting WDR11 are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study its expression, subcellular localization (e.g., cytoplasmic vs. nuclear distribution), and functional interactions in disease models. These antibodies aid in exploring WDR11's role in developmental disorders, reproductive health, and tumorigenesis. Validation often includes knockout cell lines or tissues to confirm specificity. As research advances, WDR11 antibodies remain essential for deciphering its molecular mechanisms and therapeutic potential in associated pathologies.