ZNF703抗体;ZNF703 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P12843(ZNF703 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12843(ZNF703 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The ZNF703 antibody is a key tool for studying the Zinc Finger Protein 703 (ZNF703), a member of the NET/NLZ family of transcriptional regulators. ZNF703. located on chromosome 8q21.13. has gained attention for its role in cancer biology, particularly in breast and ovarian cancers. It functions as a transcriptional repressor, interacting with chromatin-modifying complexes to regulate gene expression involved in cell proliferation, differentiation, and embryonic development. Amplification of the 8q region, leading to ZNF703 overexpression, is frequently observed in aggressive luminal B breast cancers, where it is implicated in tumor progression and therapy resistance.

The ZNF703 antibody is typically generated using recombinant ZNF703 protein or synthetic peptides as immunogens, with host species like rabbit or mouse. It is widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect ZNF703 expression levels in tissues or cell lines. Researchers employ this antibody to investigate ZNF703's oncogenic mechanisms, including its interaction with pathways like EZH2-mediated epigenetic regulation or RAC1-driven cell migration. Its validation often includes knockout/knockdown controls and correlation with clinical outcomes. As ZNF703 emerges as a potential biomarker and therapeutic target, its antibody remains critical for both basic research and translational studies in oncology.