ZMYM2抗体;ZMYM2 Antibody—艾普蒂 新品

The ZMYM2 antibody is a research tool designed to detect the zinc finger MYM-type containing 2 (ZMYM2) protein, also known as ZNF198 or FIM3. ZMYM2 is a multidomain protein involved in transcriptional regulation, chromatin remodeling, and epigenetic modifications. It contains tandem zinc finger motifs, enabling interactions with DNA, histones, or other proteins. Notably, ZMYM2 is a component of the CoREST complex, which partners with histone deacetylases (HDACs) and lysine-specific demethylase 1 (LSD1) to mediate gene silencing. Dysregulation of ZMYM2 is linked to diseases, including cancer, where chromosomal translocations (e.g., ZMYM2-FGFR1 in myeloid malignancies) drive oncogenic fusion proteins. Antibodies against ZMYM2 are typically developed in rabbits or mice, using immunogenic peptide sequences or recombinant protein fragments. They are validated for applications like Western blotting, immunoprecipitation, and immunofluorescence to study ZMYM2’s role in chromatin organization, DNA repair, or stem cell differentiation. Specificity is confirmed using knockout controls or siRNA knockdown. These antibodies aid in exploring ZMYM2’s interplay with pathways like TGF-β signaling and its potential as a therapeutic target.