ZC3HAV1抗体;ZC3HAV1 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12837(ZC3HAV1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12837(ZC3HAV1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

ZC3HAV1 (Zinc Finger CCCH-Type Antiviral Protein 1), also known as ZAP or PARP13. is a host-encoded protein critical in innate antiviral immunity. It belongs to the CCCH-type zinc finger protein family and functions as a RNA-binding protein that selectively targets viral RNAs, particularly those with high CpG content, for degradation. ZC3HAV1 exhibits broad-spectrum antiviral activity against diverse RNA viruses, including retroviruses, alphaviruses, and filoviruses, by recruiting exonucleases and the RNA degradation machinery through its N-terminal zinc finger domains. Additionally, it interacts with components of the ubiquitin-proteasome system to enhance viral restriction.

Antibodies against ZC3HAV1 are essential tools for studying its expression, subcellular localization, and mechanism in antiviral defense. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate ZC3HAV1's role in viral infections, interferon signaling, and immune regulation. Research utilizing these antibodies has revealed ZC3HAV1's dual role in directly degrading viral RNA and modulating host immune responses, making it a potential therapeutic target. Commercial ZC3HAV1 antibodies are typically validated in human or murine models, aiding studies in virology, immunology, and host-pathogen interaction research.