ZBTB40抗体;ZBTB40 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12835(ZBTB40 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12835(ZBTB40 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The ZBTB40 antibody is a crucial tool for studying the ZBTB40 protein, a member of the zinc finger and BTB (Broad-Complex, Tramtrack, and Bric-à-brac) domain-containing protein family. ZBTB40. also known as Zinc Finger Protein 852. functions as a transcription factor involved in regulating gene expression, particularly in immune cells, neurons, and certain cancer types. It contains C2H2-type zinc finger motifs and a BTB domain, enabling DNA binding and protein-protein interactions, respectively. Research highlights its role in modulating immune responses, neurodevelopment, and cellular differentiation, with emerging links to diseases such as autoimmune disorders and malignancies.

The ZBTB40 antibody is widely used in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to detect protein expression, localization, and DNA-binding activity. Its specificity is often validated via knockout controls or siRNA-mediated protein depletion. Commercial antibodies are typically raised in rabbits or mice, with monoclonal and polyclonal variants available. Studies employing this antibody have shed light on ZBTB40’s interaction with chromatin modifiers (e.g., HDACs) and its regulatory effects on genes linked to inflammation, apoptosis, and cell cycle progression.

Recent investigations also explore ZBTB40’s epigenetic roles, particularly in histone modification and transcriptional repression, underscoring its potential as a therapeutic target. However, challenges remain in standardizing antibody performance across experimental models, necessitating rigorous validation for reproducibility. Overall, the ZBTB40 antibody is pivotal for unraveling the protein’s biological significance and its implications in health and disease.