ZBTB3抗体;ZBTB3 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: A549, A172, HT-29, HEPG2 and Hela cell lysates, Primary antibody: P12833(ZBTB3 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12833(ZBTB3 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12833(ZBTB3 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The ZBTB3 antibody is a tool used to detect ZBTB3 (Zinc Finger and BTB Domain-Containing Protein 3), a member of the ZBTB family of transcription factors characterized by zinc finger motifs and a BTB (Broad-Complex, Tramtrack, Bric-à-brac) domain. ZBTB3 is implicated in transcriptional regulation, chromatin remodeling, and cellular processes such as differentiation, proliferation, and apoptosis. Its precise biological functions remain under investigation, but studies suggest potential roles in cancer biology, immune regulation, and developmental pathways. Dysregulation of ZBTB3 has been linked to tumorigenesis in certain cancers, acting as either an oncogene or tumor suppressor depending on the cellular context.

ZBTB3 antibodies are typically monoclonal or polyclonal, generated by immunizing animals (e.g., rabbits or mice) with recombinant ZBTB3 protein fragments. These antibodies are validated for applications like Western blotting, immunofluorescence, immunohistochemistry, and chromatin immunoprecipitation (ChIP). Specificity is confirmed via knockout cell lines or siRNA-mediated knockdown. Researchers use ZBTB3 antibodies to explore its expression patterns, interactions with DNA or proteins, and involvement in signaling pathways. Commercial availability from multiple suppliers facilitates its study, though validation in specific experimental systems is critical due to potential cross-reactivity. Understanding ZBTB3's role may contribute to insights into disease mechanisms and therapeutic targeting.