ZBTB11抗体;ZBTB11 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12832(ZBTB11 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The ZBTB11 antibody is a research tool designed to target the zinc finger and BTB domain-containing protein 11 (ZBTB11), a transcription factor implicated in gene regulation and cellular processes. ZBTB11 belongs to the large family of zinc finger proteins, characterized by their conserved C2H2-type zinc finger motifs and BTB (Broad-Complex, Tramtrack, and Bric-à-brac) domains, which mediate protein-protein interactions and chromatin remodeling. ZBTB11 is thought to regulate transcriptional repression or activation by binding to specific DNA sequences, though its precise biological functions remain under investigation. Studies suggest its involvement in cell cycle regulation, DNA damage response, and maintenance of genomic stability. Dysregulation of ZBTB11 has been tentatively linked to cancers, including hepatocellular carcinoma and glioblastoma, though mechanistic insights are limited.

Antibodies against ZBTB11 are typically used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression, localization, and interactions. Commercial ZBTB11 antibodies are often raised against epitopes within its N-terminal BTB domain or C-terminal zinc finger regions. Challenges in antibody validation include cross-reactivity with homologous ZBTB family members and variability due to post-translational modifications. Researchers frequently validate specificity using knockout cell lines or siRNA-mediated knockdown. Recent interest in ZBTB11 stems from its potential role in cancer progression and as a biomarker, driving demand for reliable antibodies to explore its therapeutic relevance. Suppliers such as Abcam, Cell Signaling Technology, and Santa Cruz Biotechnology offer ZBTB11-targeted reagents, though performance may vary between clones.