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  • CNTN1抗体;CNTN1 Antibody—艾普蒂
  • CNTN1抗体;CNTN1 Antibody—艾普蒂
  • CNTN1抗体;CNTN1 Antibody—艾普蒂

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CNTN1抗体;CNTN1 Antibody—艾普蒂

Rabbit Polyclonal CNTN1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-27

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：nuo***

产品详情:

中文名称：
CNTN1抗体
英文名称：
Rabbit Polyclonal CNTN1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6873 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
CNTN1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesUVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1；E-cadherin；E cadherin
Entrez GeneID999
clone7H12
WB Predicted band size135kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Monkey
ImmunogenPurified recombinant fragment of human CDH1 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Western blot analysis using CDH1 mouse mAb against LNCAP (1)?A431 (2), DU145 (3), PC-3 (4), MCF-7 (5), PC-12 (6), NIH/3T3 (7), C6 (8) and COS7 (9) cell lysate.    


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       Flow cytometric analysis of Hela cells using CDH1 mouse mAb (green) and negative control (purple).    


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       Immunohistochemical analysis of paraffin-embedded human gastric cancer tissues (left) and lung cancer tissues (right) using CDH1 mouse mAb with DAB staining.    


           

参考文献

以下是关于CNTN1抗体的3篇参考文献及其摘要内容：

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1. **文献名称**: *Contactin-1 autoantibodies in patients with autoimmune encephalitis: clinical correlates and diagnostic implications*

**作者**: Miske R, et al.

**摘要**: 该研究报道了在部分自身免疫性脑炎患者血清中检测到CNTN1抗体，发现其与认知功能障碍、小脑共济失调及周围神经病变相关，提示CNTN1抗体可能通过干扰神经元黏附导致神经传导异常。

2. **文献名称**: *Chronic inflammatory demyelinating polyneuropathy with autoantibodies against contactin-1: a distinct clinical phenotype*

**作者**: van der Veen S, et al.

**摘要**: 研究者发现CNTN1抗体阳性的慢性炎症性脱髓鞘性神经病(CIDP)患者表现为远端对称性运动障碍和感觉缺失，对静脉免疫球蛋白治疗反应较差，提示CNTN1抗体可能是CIDP亚型分层的生物标志物。

3. **文献名称**: *Contactin-1 antibodies induce paranodal dissection in experimental autoimmune models*

**作者**: Pascual-Goñi A, et al.

**摘要**: 通过动物模型证实，CNTN1抗体可靶向结合周围神经的结旁区域，导致髓鞘结构破坏和神经传导阻滞，为抗体介导的神经损伤机制提供了直接证据。

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如需更多文献，可进一步检索PubMed或Google Scholar，关键词包括“CNTN1 antibody”或“Contactin-1 autoimmunity”。部分研究可能聚焦于抗体检测方法或与特定疾病(如副肿瘤综合征)的关联。

       

背景信息

The CNTN1 antibody targets Contactin-1 (CNTN1), a cell adhesion molecule belonging to the immunoglobulin superfamily. CNTN1 is predominantly expressed in the nervous system, where it plays critical roles in axon guidance, myelination, and synaptic plasticity. It interacts with proteins like contactin-associated protein 1 (Caspr1) to form membrane complexes essential for neuron-glia communication and node of Ranvier organization.

Autoantibodies against CNTN1 are implicated in autoimmune neurological disorders. They are strongly associated with chronic inflammatory demyelinating polyneuropathy (CIDP), particularly in subsets of patients with aggressive, treatment-resistant phenotypes. These antibodies disrupt CNTN1-Caspr1 interactions, impairing paranodal junction integrity and leading to nerve conduction abnormalities. CNTN1 antibodies are also linked to paraneoplastic neurological syndromes, often coexisting with malignancies like lymphomas or solid tumors.

Clinically, detection of CNTN1 antibodies (via serum or CSF testing) aids in diagnosing autoimmune neuropathies and guiding treatment. Patients with CNTN1 autoimmunity may exhibit poor response to intravenous immunoglobulin (IVIg) but show improvement with B-cell-targeted therapies like rituximab. Research continues to explore CNTN1’s broader role in neuroinflammation and its potential as a biomarker for disease stratification. Understanding CNTN1 antibody mechanisms offers insights into neuroglial dysfunction and novel therapeutic strategies for autoimmune neurological conditions.

       
CNTN1抗体;CNTN1;CNTN1 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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