PAPPA-AS1抗体;PAPPA-AS1 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12827(PAPPA-AS1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

PAPPA-AS1 is a long non-coding RNA (lncRNA) transcribed from the antisense strand of the pregnancy-associated plasma protein A (PAPPA) gene locus. It has gained attention for its regulatory roles in various biological processes, particularly in cancer. Studies suggest PAPPA-AS1 modulates gene expression through epigenetic mechanisms, RNA-protein interactions, or by acting as a competing endogenous RNA (ceRNA) to influence mRNA stability and translation. Dysregulation of PAPPA-AS1 has been linked to tumor progression, metastasis, and drug resistance in cancers such as breast, ovarian, and gastric cancer.

PAPPA-AS1 antibodies are specialized tools designed to detect and study this lncRNA’s expression, localization, and interactions. These antibodies are typically validated for applications like Western blotting, immunofluorescence, or RNA immunoprecipitation (RIP). Their development often involves immunizing hosts with peptide sequences unique to PAPPA-AS1 or its associated protein complexes. Validating specificity is critical, often achieved via knockdown/overexpression experiments or CRISPR-based approaches. Clinically, PAPPA-AS1 antibodies may aid in exploring its potential as a diagnostic biomarker or therapeutic target, though research remains in early stages. Challenges include ensuring cross-reactivity avoidance and optimizing detection in diverse sample types.