PLAG1抗体;PLAG1 Antibody—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hepg2, A431, Hela and A549 cell lysates, Primary antibody: P12810(PLAG1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12810(PLAG1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

**Background of PLAG1 Antibody**

The PLAG1 (Pleomorphic Adenoma Gene 1) antibody is a tool used to detect the PLAG1 protein, a zinc finger transcription factor encoded by the *PLAG1* gene located on chromosome 8q12. PLAG1 plays a critical role in regulating genes involved in cell proliferation, growth, and apoptosis, notably targeting pathways like the IGF-II (insulin-like growth factor 2) signaling cascade. It is physiologically expressed during embryonic development but is typically silenced in adult tissues.

PLAG1 gains prominence in oncology due to its association with tumorigenesis. Chromosomal translocations involving *PLAG1*, such as t(3;8) or t(8;12), result in its overexpression, driving neoplasms like pleomorphic adenomas of the salivary gland, lipoblastomas, and hepatoblastomas. These aberrations often fuse *PLAG1* with promoter regions of partner genes (e.g., *CTNNB1* or *CHCHD7*), causing ectopic PLAG1 activation.

PLAG1 antibodies are vital in research and diagnostics. They enable detection of PLAG1 protein expression via techniques like immunohistochemistry (IHC), Western blotting, or immunofluorescence (IF), aiding in the classification of PLAG1-driven tumors. For instance, PLAG1 immunostaining helps differentiate lipoblastomas from histologic mimics like liposarcomas. Commercially available as monoclonal or polyclonal variants, these antibodies are validated for specificity across human and murine tissues, supporting both mechanistic studies and clinical diagnostics in cancer pathology.

(Word count: 248)