TYRP1抗体;TYRP1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12803(TYRP1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P12803(TYRP1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

TYRP1 (Tyrosinase-Related Protein 1) is a melanogenic enzyme encoded by the *TYRP1* gene, primarily expressed in melanocytes. It plays a critical role in melanin biosynthesis by stabilizing tyrosinase (TYR), the rate-limiting enzyme in the pathway, and modulating the oxidation of 5.6-dihydroxyindole-2-carboxylic acid (DHICA) to produce eumelanin. Mutations in *TYRP1* are linked to oculocutaneous albinism type 3 (OCA3), characterized by reduced pigmentation and vision abnormalities. TYRP1 is also implicated in melanoma progression, as its overexpression correlates with tumor aggressiveness and resistance to therapy.

TYRP1 antibodies are essential tools for studying melanocyte biology, pigmentation disorders, and melanoma. These antibodies enable the detection and quantification of TYRP1 in tissues or cell lysates via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They help elucidate TYRP1's role in melanosome structure, melanin polymerization, and its interplay with other melanogenic proteins. In clinical research, TYRP1 antibodies aid in diagnosing pigmentary diseases and serve as potential biomarkers for melanoma stratification. Commercially available TYRP1 antibodies vary in clonality (monoclonal/polyclonal), species reactivity, and applications, requiring validation for specificity to avoid cross-reactivity with homologous proteins like TYR or TYRP2.