Fmoc-Gly-Gly-Ser(Psi(Me,Me)Pro)-OH

Fmoc-Gly-Gly-Ser(Psi(Me,Me)Pro)-OH  属于定制产品，

The compound Fmoc-Gly-Gly-Ser(Ψ(Me,Me)Pro)-OH is a peptide derivative containing a pseudoproline dipeptide mimic (Ψ(Me,Me)Pro) attached to a serine residue. Here’s a breakdown of its structure and significance:

Structure Analysis:

1. Fmoc (9-Fluorenylmethoxycarbonyl) – A protecting group for the N-terminal amine, commonly used in solid-phase peptide synthesis (SPPS).

2. Gly-Gly – A dipeptide sequence of two glycine residues.

3. Ser(Ψ(Me,Me)Pro) – A serine residue linked to a pseudoproline (Ψ(Me,Me)Pro) moiety:

• Ψ(Me,Me)Pro is a dipeptide mimic where serine (or threonine) forms an oxazolidine/thiazolidine ring with a dimethyl-substituted proline derivative.

• This structure helps reduce aggregation and improve solubility during peptide synthesis.

4. -OH – The C-terminus is free (unprotected), making it suitable for further coupling in SPPS.

Role in Peptide Synthesis:

• Pseudoprolines (like Ser(Ψ(Me,Me)Pro)) are turn inducers that help prevent β-sheet formation, which can cause poor coupling efficiency and low yields in difficult sequences.

• They are cleavable under standard acidic deprotection conditions (e.g., TFA).

Applications:

• Used in difficult peptide syntheses where aggregation is a problem.

• Improves the efficiency of long or hydrophobic peptide sequences.

Would you like details on synthesis protocols or handling precautions for this compound?