HOXD1抗体;HOXD1 Antibody—艾普蒂

The HOXD1 antibody is a research tool designed to detect HOXD1. a protein encoded by the HOXD1 gene within the Homeobox (HOX) gene family. HOX genes play critical roles in embryonic development, particularly in establishing body segmentation and axial patterning. HOXD1. located on chromosome 2 (2q31.1), belongs to the HOXD cluster (paralog groups 1-13) and functions as a transcription factor regulating gene expression during morphogenesis. It contains a conserved 60-amino acid homeodomain that binds DNA to control developmental pathways. Studies link HOXD1 to limb development, neural tube formation, and organogenesis. Dysregulation of HOXD1 is implicated in cancers (e.g., breast, colorectal) and congenital disorders, suggesting roles in cell proliferation and differentiation. HOXD1 antibodies (polyclonal/monoclonal) are used in techniques like Western blot, immunohistochemistry, and immunofluorescence to study protein localization, expression levels, and interactions in tissues/cells. Their specificity is validated through knockout controls or peptide blocking. Research applications focus on developmental biology, oncogenesis, and regenerative medicine, with some exploring HOXD1's crosstalk with signaling pathways (e.g., Wnt, BMP). Challenges include cross-reactivity with homologous HOX proteins, necessitating careful antibody validation for experimental accuracy.