MYF6抗体;MYF6 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12788(MYF6 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The MYF6 antibody targets the MYF6 protein, a member of the myogenic regulatory factor (MRF) family, which includes key transcription factors (MyoD, Myf5. myogenin, and MYF6) essential for skeletal muscle development and differentiation. MYF6. also known as MRF4 or Herculin, plays dual roles in myogenesis: it promotes the differentiation of myoblasts into mature muscle fibers and maintains the quiescent state of muscle stem cells (satellite cells). Structurally, MYF6 contains a conserved basic helix-loop-helix (bHLH) domain that enables DNA binding and dimerization with other bHLH proteins to regulate gene expression.

Antibodies against MYF6 are widely used in research to study muscle regeneration, developmental biology, and diseases such as muscular dystrophies or rhabdomyosarcoma. They enable the detection and localization of MYF6 in tissues via techniques like Western blot, immunohistochemistry, and immunofluorescence. Studies using MYF6 antibodies have revealed its temporal expression pattern, peaking during late embryonic myogenesis and postnatal muscle growth. Dysregulation of MYF6 is linked to impaired muscle repair and tumorigenesis, underscoring its therapeutic relevance. Commercial MYF6 antibodies are typically validated for specificity across species, including human, mouse, and rat, facilitating cross-disciplinary research in muscle biology and regenerative medicine.