TMPRSS6抗体;TMPRSS6 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12775(TMPRSS6 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of TMPRSS6 Antibodies**

TMPRSS6 (Transmembrane Serine Protease 6), also known as matriptase-2. is a membrane-bound serine protease primarily expressed in the liver. It plays a critical role in systemic iron homeostasis by regulating the expression of hepcidin, a key hormone controlling iron absorption and recycling. TMPRSS6 cleaves membrane-bound hemojuvelin (HJV), a co-receptor for the bone morphogenetic protein (BMP) signaling pathway, thereby suppressing hepcidin production. Dysregulation of TMPRSS6 is linked to iron-related disorders, including iron-refractory iron deficiency anemia (IRIDA) and hereditary hemochromatosis.

Antibodies targeting TMPRSS6 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They enable detection of TMPRSS6 in tissues or cell lines via techniques like Western blot, immunohistochemistry, or flow cytometry. Additionally, these antibodies are used to investigate molecular mechanisms underlying TMPRSS6 mutations or polymorphisms associated with diseases.

Recent research explores therapeutic potential, such as modulating TMPRSS6 activity to treat iron imbalance. For example, anti-TMPRSS6 monoclonal antibodies or inhibitory strategies may help elevate hepcidin in iron-overload conditions or suppress it in iron deficiency. However, challenges remain in achieving tissue-specific targeting and minimizing off-effects. Overall, TMPRSS6 antibodies serve as vital reagents for advancing basic research and developing novel diagnostics or therapies for iron metabolism disorders.