SERPINH1抗体;SERPINH1 Antibody—艾普蒂 新品

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hepg2, Hela and A431 cell, Human fetal liver tissue lysates, Primary antibody: P12750(SERPINH1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12750(SERPINH1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

**Background of SERPINH1 Antibody**

SERPINH1 (Serpin Family H Member 1), also known as HSP47 or collagen-binding protein 2. is a member of the serine protease inhibitor (serpin) superfamily. Unlike typical serpins, SERPINH1 does not inhibit proteases but acts as a chaperone critical for collagen biosynthesis. It binds specifically to procollagen in the endoplasmic reticulum, stabilizing its structure and ensuring proper folding, secretion, and assembly into extracellular matrices.

SERPINH1 antibodies are essential tools for studying collagen regulation and extracellular matrix (ECM) dynamics. These antibodies enable detection and quantification of SERPINH1 in various experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence. Research highlights its role in fibrotic diseases (e.g., liver fibrosis, pulmonary fibrosis), cancer progression (via ECM remodeling), and developmental biology (tissue morphogenesis). Dysregulation of SERPINH1 is linked to pathological collagen accumulation, making it a biomarker for fibrosis and a potential therapeutic target.

Antibodies against SERPINH1 are also used to explore its stress-inducible expression under conditions like heat shock, underscoring its dual identity as a heat shock protein. Validation of these antibodies includes specificity checks in knockout models or siRNA-treated cells to ensure accurate detection. Overall, SERPINH1 antibodies are pivotal in advancing understanding of collagen biology and ECM-related diseases.