HOXD12抗体;HOXD12 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12746(HOXD12 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12746(HOXD12 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The HOXD12 antibody is a tool used to detect the HOXD12 protein, a member of the HOX gene family, which plays critical roles in embryonic development, body patterning, and cellular differentiation. HOXD12. part of the HOXD cluster on chromosome 2. encodes a transcription factor that regulates target genes involved in limb development, organogenesis, and tissue homeostasis. Dysregulation of HOXD12 has been linked to developmental disorders and cancers, including colorectal, breast, and prostate malignancies, where it may act as an oncogene or tumor suppressor depending on context.

HOXD12 antibodies are typically produced in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable researchers to study HOXD12's expression patterns, subcellular localization (primarily nuclear), and interactions via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validated antibodies are essential for specificity, often confirmed through knockout controls or siRNA silencing.

In research, HOXD12 antibodies help explore developmental pathways, cancer mechanisms, and potential therapeutic targets. Their application extends to diagnostic studies, particularly in cancers with HOXD12 misexpression. Proper validation ensures reliability in distinguishing HOXD12 from paralogs (e.g., HOXD11/D13), minimizing cross-reactivity. Overall, HOXD12 antibodies are vital for unraveling the gene's multifaceted roles in health and disease.