HOXD3抗体;HOXD3 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: K562, Raji, A549, Hela, Jurkat cell lysates, Primary antibody: P12744(HOXD3 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12744(HOXD3 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The HOXD3 antibody is a valuable tool in biomedical research, primarily used to study the Homeobox D3 (HOXD3) protein, a member of the HOX family of transcription factors. HOX genes, highly conserved across species, play critical roles in embryonic development, particularly in establishing body patterning, organogenesis, and cell differentiation. HOXD3 specifically regulates processes like cell migration, extracellular matrix remodeling, and tissue morphogenesis by modulating target genes, including integrins and matrix metalloproteinases (MMPs). Dysregulation of HOXD3 has been implicated in pathological conditions, such as cancer metastasis, where it promotes invasive behavior by enhancing cellular motility and angiogenesis.

Researchers employ HOXD3 antibodies in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression levels, localization, and dynamics in tissues or cultured cells. These studies help elucidate HOXD3's role in development and disease, particularly its contribution to tumor progression and epithelial-to-mesenchymal transition (EMT). The antibody's specificity for HOXD3. validated through knockdown or knockout controls, ensures reliable data interpretation. Additionally, HOXD3 antibodies may have potential diagnostic or therapeutic applications, as HOXD3 overexpression correlates with poor prognosis in cancers like melanoma and breast cancer. Ongoing research continues to explore its interactions with signaling pathways, such as Wnt and TGF-β, further underscoring its biological significance.