DES抗体;DES Antibody—艾普蒂

+ +

•  

   

     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: U937 cells, Primary antibody: P08262(RNASE3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P08262(RNASE3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P08262(RNASE3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of DES Antibodies**

DES antibodies target desmin, a 52-53 kDa intermediate filament protein crucial for maintaining structural and functional integrity in muscle cells. Predominantly expressed in skeletal, cardiac, and smooth muscle tissues, desmin forms a cytoskeletal network that stabilizes sarcomeres, connects myofibrils to organelles, and facilitates force transmission during contraction.

In research and diagnostics, DES antibodies are widely used as immunohistochemical markers to identify muscle-specific differentiation in tumors (e.g., rhabdomyosarcoma, leiomyosarcoma) and to study muscle-related pathologies. Mutations in the *DES* gene cause desminopathies, a subset of myopathies characterized by abnormal desmin aggregation, leading to muscle weakness, cardiomyopathy, or respiratory failure. DES antibodies help detect these intracellular protein aggregates in tissue samples, aiding diagnosis.

Additionally, DES antibodies are utilized in studying muscle regeneration and development, as desmin is upregulated during myoblast differentiation. In non-muscle contexts, low desmin levels are observed in certain endothelial or fibroblastic cells, requiring careful interpretation. Techniques like Western blot, immunofluorescence, and flow cytometry employ DES antibodies to explore desmin's role in cellular mechanics, disease mechanisms, and therapeutic responses. Their specificity and reliability make DES antibodies essential tools in both basic muscle biology and clinical diagnostics.