ARL5A抗体;ARL5A Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12700(ARL5A Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12700(ARL5A Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The ADP-ribosylation factor-like 5A (ARL5A) protein is a member of the ARF/ARL family of small GTP-binding proteins, which regulate intracellular trafficking, membrane remodeling, and signaling. ARL5A, also known as ARL11. is evolutionarily conserved and shares structural homology with other ARL family members but exhibits distinct functional characteristics. It localizes to the Golgi apparatus and endosomal compartments, suggesting roles in vesicular transport or organelle dynamics. Studies link ARL5A to lipid metabolism, cell cycle regulation, and tumor suppression, though its precise molecular mechanisms remain under investigation.

ARL5A antibodies are essential tools for studying its expression, localization, and interactions. These antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments corresponding to conserved regions of ARL5A. Validation methods include Western blotting to confirm specificity (e.g., detecting a ~22 kDa band), immunofluorescence for subcellular localization, and knockdown/knockout controls to rule off-target signals. Commercial and custom ARL5A antibodies have been employed in cancer research, particularly exploring its potential tumor-suppressive role in colorectal and gastric cancers. However, ARL5A's tissue distribution, post-translational modifications, and disease-associated pathways remain poorly characterized, necessitating further research. Reliable antibodies are critical for elucidating ARL5A's biological functions and therapeutic relevance.