SLC8A1抗体;SLC8A1 Antibody—艾普蒂 新品

The SLC8A1 antibody is a research tool designed to detect the sodium-calcium exchanger 1 (NCX1), a transmembrane protein encoded by the SLC8A1 gene. NCX1 plays a critical role in maintaining intracellular calcium homeostasis by exchanging three sodium ions for one calcium ion across the plasma membrane. This exchanger is particularly vital in excitable tissues, such as the heart, where it regulates cardiac contractility by mediating calcium efflux during relaxation. Dysregulation of NCX1 has been linked to cardiovascular pathologies, including heart failure, arrhythmias, and hypertension. SLC8A1 antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to study NCX1 expression, localization, and function in both physiological and disease contexts. These antibodies are essential for investigating tissue-specific expression patterns, such as its high abundance in cardiac muscle, and for validating experimental models of calcium signaling disorders. Researchers also utilize SLC8A1 antibodies to explore NCX1's role in cellular responses to stress, such as ischemia-reperfusion injury, and its interaction with regulatory proteins. Validating antibody specificity via knockout controls or peptide blocking is crucial to ensure accurate detection, given the protein's structural complexity and splice variants.