TNIK 抗体;TNIK Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12690(TNIK  Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

TNIK (Traf2- and Nck-interacting kinase), a serine/threonine kinase belonging to the MAPK family, plays a critical role in regulating cellular signaling pathways, particularly the Wnt/β-catenin cascade. First identified in 2001. TNIK interacts with Traf2 and Nck adaptor proteins, influencing cytoskeletal dynamics, cell migration, and proliferation. Its involvement in Wnt signaling—specifically through phosphorylation of TCF4/β-catenin complexes—links TNIK to transcriptional regulation of genes driving cell cycle progression and oncogenesis. Dysregulation of TNIK is implicated in diseases like cancer, obesity, and neurological disorders, with elevated TNIK expression observed in colorectal, gastric, and liver cancers.

TNIK antibodies are essential tools for studying its expression, localization, and functional roles. They enable detection via Western blotting, immunoprecipitation, and immunofluorescence, aiding research into TNIK’s mechanistic contributions to pathologies. Recent studies highlight TNIK as a therapeutic target, with inhibitors showing anti-tumor efficacy in preclinical models. Antibodies also facilitate biomarker discovery, as TNIK overexpression correlates with poor prognosis in certain cancers. However, challenges remain in optimizing antibody specificity due to structural similarities with other kinases. Ongoing research focuses on refining antibody-based assays and exploring TNIK’s potential in personalized medicine, particularly in targeting Wnt-dependent cancers resistant to conventional therapies.