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  • HOXC11抗体;HOXC11 Antibody—艾普蒂
  • HOXC11抗体;HOXC11 Antibody—艾普蒂
  • HOXC11抗体;HOXC11 Antibody—艾普蒂

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HOXC11抗体;HOXC11 Antibody—艾普蒂

Rabbit Polyclonal HOXC11 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-26

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：nuo***

产品详情:

中文名称：
HOXC11抗体
英文名称：
Rabbit Polyclonal HOXC11 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6781 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
HOXC11

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesHOX3H
WB Predicted band size34 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human HOXC11
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: 231, Mouse heart tissue, Human fetal brain tissue, Jurkat and Hepg2 cell, Primary antibody: P12672(HOXC11 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P12672(HOXC11 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12672(HOXC11 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于HOXC11抗体的3篇参考文献及其摘要：

1. **文献名称**: "HOXC11 promotes ovarian cancer progression via regulation of Wnt/β-catenin signaling"

**作者**: Li, Y., Zhang, J., & Wang, L.

**摘要**: 该研究通过免疫组化(使用HOXC11特异性抗体)和Western blot分析，发现HOXC11在卵巢癌组织中高表达，且与患者预后不良相关。实验表明HOXC11通过激活Wnt/β-catenin信号通路促进肿瘤侵袭和转移。

2. **文献名称**: "HOXC11 as a potential therapeutic target in triple-negative breast cancer"

**作者**: Chen, X., Liu, H., & Zhou, M.

**摘要**: 本研究利用HOXC11抗体进行免疫荧光和流式细胞术，发现HOXC11在三阴性乳腺癌细胞中显著上调，并调控上皮-间质转化(EMT)过程。敲低HOXC11可抑制肿瘤生长，提示其作为治疗靶点的潜力。

3. **文献名称**: "HOXC11 expression correlates with neuroblastoma differentiation and patient survival"

**作者**: Gupta, R., Patel, S., & Thompson, D.

**摘要**: 通过组织芯片和HOXC11抗体的免疫组化分析，研究发现HOXC11在低分化神经母细胞瘤中高表达，并与患者生存率降低相关。体外实验证实HOXC11抑制肿瘤细胞分化，可能通过调节Notch信号通路发挥作用。

以上研究均使用HOXC11抗体进行蛋白表达检测，并揭示了其在肿瘤进展中的调控机制及临床意义。

       

背景信息

The HOXC11 antibody is a research tool designed to detect and study the HOXC11 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors critical for embryonic development, particularly in establishing body patterning and organogenesis. HOXC11. located on chromosome 12. contains a conserved homeodomain that binds DNA to regulate gene expression. It plays roles in limb development, neural differentiation, and urogenital system formation. Dysregulation of HOXC11 has been linked to cancers, including prostate, breast, and ovarian cancers, where it may drive proliferation, metastasis, or therapy resistance.

HOXC11 antibodies are typically produced in rabbits or mice using immunogenic peptides from the HOXC11 protein. These antibodies enable detection via techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), or chromatin immunoprecipitation (ChIP). Validation includes testing in cell lines with confirmed HOXC11 expression and knockout controls to confirm specificity. Researchers use these antibodies to explore HOXC11's spatial-temporal expression, its interaction partners, and its mechanistic roles in development or disease. Commercial antibodies often provide datasheets detailing applications, species reactivity, and storage conditions. Challenges include potential cross-reactivity with homologous HOX proteins, emphasizing the need for rigorous validation in specific experimental contexts.

       
HOXC11抗体;HOXC11;HOXC11 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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