PRH2抗体;PRH2 Antibody—艾普蒂 新品

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cell lysate, Primary antibody: P12669(PRH2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12669(PRH2 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The PRH2 antibody targets the Proline-Rich Protein HaeIII Subfamily 2 (PRH2), a member of the proline-rich salivary protein family encoded by the *PRH2* gene. These proteins are primarily expressed in salivary glands and play roles in oral lubrication, microbial defense, and enamel pellicle formation. PRH2. specifically, contributes to tooth enamel maturation by binding to calcium ions and regulating mineral deposition. Its genetic variants are associated with dental conditions like amelogenesis imperfecta, characterized by defective enamel formation.

Antibodies against PRH2 are valuable tools in dental and oral biology research. They enable the detection and localization of PRH2 in tissues, aiding studies on salivary protein functions, enamel biomineralization, and oral microbiota interactions. Commercially available PRH2 antibodies are typically developed in animal hosts (e.g., rabbits) using immunogenic peptide sequences, and their specificity is validated via Western blotting, immunohistochemistry, or ELISA. Recent studies also explore PRH2's potential as a biomarker for oral diseases or systemic conditions affecting mineral metabolism. Challenges include cross-reactivity with homologous proteins (e.g., PRH1) due to sequence similarities, necessitating rigorous validation. Ongoing research focuses on clarifying PRH2's mechanistic roles in enamel pathologies and its interactions with other enamel matrix proteins.