HOXA5抗体;HOXA5 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12667(HOXA5 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12667(HOXA5 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The HOXA5 antibody is a crucial tool for studying the HOXA5 protein, a member of the homeobox (HOX) gene family that regulates embryonic development and cellular differentiation. HOXA5. located on chromosome 7p15.2. encodes a DNA-binding transcription factor containing a conserved homeodomain, which plays pivotal roles in organogenesis, axial patterning, and tissue identity. Dysregulation of HOXA5 has been implicated in cancer, particularly as a tumor suppressor in breast, lung, and colorectal cancers, where its downregulation correlates with metastasis and poor prognosis.

HOXA5 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect HOXA5 expression and localization in tissues or cell lines. These antibodies help elucidate HOXA5’s role in gene regulatory networks, including its interaction with p53 to modulate apoptosis or its suppression of oncogenic pathways like Wnt/β-catenin. Researchers also employ HOXA5 antibodies to explore epigenetic silencing mechanisms, such as promoter hypermethylation, which contributes to HOXA5 loss in malignancies. Challenges include ensuring antibody specificity due to homology among HOX family proteins. Validated antibodies are essential for diagnostic applications, such as assessing HOXA5 as a biomarker for cancer progression or therapeutic response. Overall, HOXA5 antibodies bridge molecular insights into developmental biology and disease pathology, offering potential for translational research.