HOXB6抗体;HOXB6 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12664(HOXB6 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P12664(HOXB6 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

HOXB6 antibody is a research tool targeting the HOXB6 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors critical for embryonic development, particularly in establishing body patterning and organogenesis. The HOXB6 protein contains a conserved DNA-binding homeodomain, enabling it to regulate downstream gene expression by binding specific DNA sequences. It plays roles in hematopoietic differentiation, limb development, and tissue homeostasis.

Dysregulation of HOXB6 has been implicated in multiple cancers. Overexpression is observed in leukemia, colorectal cancer, and breast cancer, where it may promote cell proliferation, metastasis, or therapy resistance by modulating pathways like Wnt/β-catenin or epithelial-mesenchymal transition (EMT). Conversely, reduced HOXB6 expression is linked to poor prognosis in some malignancies, suggesting context-dependent functions.

HOXB6 antibodies are widely used in basic and clinical research to detect protein expression/localization via techniques like Western blot, immunohistochemistry (IHC), or immunofluorescence (IF). Commercial antibodies are typically validated for specificity using knockout controls or siRNA knockdown. Researchers utilize these antibodies to explore HOXB6's role in developmental biology, cancer mechanisms, or as a potential diagnostic/prognostic biomarker. Cross-reactivity with other HOX family proteins remains a key validation consideration due to structural similarities.