KCNH1抗体;KCNH1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12658(KCNH1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12658(KCNH1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The KCNH1 antibody targets the potassium voltage-gated channel subfamily H member 1 (KCNH1), a protein encoded by the *KCNH1* gene. KCNH1. also known as EAG1 or Kv10.1. belongs to the Ether-à-go-go (EAG) family of voltage-gated potassium channels. These channels regulate cellular excitability and signaling by controlling potassium ion flow across membranes. KCNH1 is predominantly expressed in the brain and plays critical roles in neuronal development, synaptic plasticity, and cell proliferation. Dysregulation of KCNH1 has been linked to neurodevelopmental disorders such as Temple-Baraitser syndrome and Zimmermann-Laband syndrome, characterized by intellectual disability, epilepsy, and craniofacial abnormalities. Additionally, KCNH1 is overexpressed in certain cancers (e.g., glioblastoma, colorectal cancer), where it promotes tumor growth and invasiveness.

The KCNH1 antibody is widely used in research to detect and quantify KCNH1 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in studying the channel’s physiological functions, pathological mechanisms, and interactions with signaling pathways. Specific antibodies may target distinct regions of the KCNH1 protein, such as its extracellular domains or intracellular C-terminus, enabling investigations into structure-function relationships. As a research tool, the antibody contributes to understanding KCNH1’s role in neuronal disorders and cancer, potentially guiding therapeutic strategies targeting this channel. Validation of antibody specificity is crucial to ensure accurate detection, given structural similarities among potassium channel family members.