GZMH抗体;GZMH Antibody—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela and 231 cell lysates, Primary antibody: P12651(GZMH Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer using P12651(GZMH Antibody) at dilution 1/75. (Original magnification: ×200)    

  
  

Granzyme H (GZMH) antibody is a tool used to detect and study the function of GZMH, a serine protease in the granzyme family. Granzymes are primarily expressed in cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, where they contribute to immune defense by inducing apoptosis in virus-infected or tumorigenic cells. Unlike the well-characterized Granzyme B (GZMB), which cleaves caspases to trigger programmed cell death, GZMH exhibits distinct substrate specificity and enzymatic activity. It is thought to play a role in alternative cell death pathways or immune modulation, though its precise biological mechanisms remain less understood.

Research suggests GZMH may be involved in antiviral responses, particularly against herpesviruses and poxviruses, and its expression is upregulated in certain cancers, autoimmune disorders, and chronic inflammatory conditions. GZMH antibodies enable the detection of this protein in tissues or cells via techniques like Western blotting, immunohistochemistry, or flow cytometry, aiding investigations into its localization, expression patterns, and functional interactions. Recent studies also explore its potential as a biomarker for disease prognosis or therapeutic targeting. However, cross-reactivity with other granzymes and variability in antibody specificity require careful validation in experimental settings. Ongoing research aims to clarify GZMH's unique contributions to immune regulation and pathology.