GADD45GIP1抗体;GADD45GIP1 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12640(GADD45GIP1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12640(GADD45GIP1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The GADD45GIP1 (Growth Arrest and DNA Damage-inducible 45 Gamma Interacting Protein 1) antibody is a tool used to study the function of the GADD45GIP1 protein, a regulator of cell cycle progression and stress response. GADD45GIP1 interacts with members of the GADD45 family, particularly GADD45γ, to modulate their roles in DNA repair, apoptosis, and cell cycle arrest. This protein is implicated in maintaining genomic stability and responding to cellular stressors like radiation, oxidative damage, or chemotherapeutic agents.

Research involving GADD45GIP1 antibodies often focuses on its expression patterns under stress conditions, its interaction networks, and its potential tumor-suppressive or oncogenic roles in cancers. Studies suggest that GADD45GIP1 may act as a scaffold protein, influencing signaling pathways such as p38 MAPK and NF-κB, which are critical for stress adaptation and inflammation regulation. Antibodies against GADD45GIP1 enable detection of its expression levels via techniques like Western blotting, immunohistochemistry, or immunofluorescence, aiding investigations into its localization and function in tissues or cultured cells.

Altered GADD45GIP1 expression has been observed in various cancers, neurodegenerative diseases, and metabolic disorders, making it a biomarker of interest. The antibody's utility extends to exploring therapeutic targets linked to cell survival, DNA damage response, and disease mechanisms. Validated antibodies with high specificity are essential to ensure reliable experimental outcomes in these contexts.