CES4A抗体;CES4A Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12637(CES4A Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The CES4A antibody is a immunological tool designed to detect carboxylesterase 4A (CES4A), a member of the carboxylesterase enzyme family. These enzymes play critical roles in hydrolyzing ester-containing compounds, including drugs, environmental toxins, and endogenous lipids. CES4A is primarily expressed in the liver and intestines, where it contributes to xenobiotic metabolism and lipid homeostasis. Research on CES4A has gained momentum due to its potential involvement in drug efficacy (e.g., activation of prodrugs) and detoxification pathways, with implications for personalized medicine and toxicology studies.

The antibody is typically developed in host species like rabbits or mice using immunogenic peptides or recombinant CES4A protein. It enables the identification and quantification of CES4A expression through techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Validated applications often include investigating tissue-specific expression patterns, dysregulation in metabolic disorders, or interactions with therapeutic agents. Specificity is confirmed using knockout controls or siRNA-mediated CES4A suppression. Commercial variants may vary in clonality (monoclonal/polyclonal), conjugates (e.g., HRP, fluorescent tags), and species reactivity. Recent studies utilizing CES4A antibodies have explored its role in cancer chemoresistance and lipid-associated diseases, highlighting its growing relevance in biomedical research.