JUNB抗体;JUNB Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P12617(JUNB Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12617(JUNB Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

JUNB antibody is a research tool used to detect and study the JUNB protein, a member of the AP-1 (Activator Protein 1) transcription factor family. JUNB, along with other AP-1 components like c-JUN and FOS proteins, forms dimeric complexes that regulate gene expression by binding to specific DNA sequences. It plays critical roles in cellular processes, including proliferation, differentiation, apoptosis, and immune responses. Dysregulation of JUNB has been linked to cancers (e.g., lymphoma, breast cancer), inflammatory diseases, and autoimmune disorders.

The JUNB antibody is essential for identifying JUNB expression levels, subcellular localization, and interactions in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). It helps researchers explore JUNB's functional mechanisms, such as its dual role in tumorigenesis—acting as both an oncogene and tumor suppressor depending on context. For example, JUNB overexpression is associated with cutaneous T-cell lymphoma, while its loss may promote genomic instability.

Commercial JUNB antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of human, mouse, or rat JUNB. Validation includes testing for specificity via knockout controls or siRNA knockdown. Researchers rely on these antibodies to investigate JUNB's involvement in signaling pathways (e.g., TGF-β, MAPK) and its regulatory effects on cytokines and cell cycle proteins, advancing therapeutic discoveries in oncology and immunology.