GANAB抗体;GANAB Antibody—艾普蒂新品

Rabbit Polyclonal GANAB Antibody

询价 20μl 起订

50μl 起订

100μl 起订

上海更新日期：2025-05-26

上海切尔齐生物科技有限公司

非会员

联系人：周***

电话：027***

手机：180***

邮箱：nuo***

产品详情:

中文名称：: GANAB抗体

英文名称：: Rabbit Polyclonal GANAB Antibody

品牌：: 艾普蒂

产地：: 武汉

保存条件：: Stored at -20°C for 6745 year. Avoid repeated freeze / thaw cycles.

产品类别：: 抗体

重组：: 否

应用：: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA

种属反应性：: Human,Mouse,Rat

宿主：: Rabbit

偶联物：: 无

靶点：: GANAB

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/50-1/100	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	1/5000-1/10000	Human,Mouse,Rat

产品详情

Aliases	G2AN; GIIA; PKD3; GLUII
WB Predicted band size	107 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Synthetic peptide of human GANAB
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: LOVO and 293T cell lysates, Primary antibody: P12601(GANAB Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes
The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12601(GANAB Antibody) at dilution 1/25. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12601(GANAB Antibody) at dilution 1/25. (Original magnification: ×200)

参考文献

以下是关于GANAB抗体的3篇文献示例(注：以下内容为模拟示例，实际文献请通过学术数据库查询)：

1. **文献名称**: "GANAB mutations contribute to autosomal dominant polycystic liver disease by impairing enzyme activity"

**作者**: Porath B, et al.

**摘要**: 研究分析了GANAB基因突变导致多囊肝病的分子机制，利用GANAB抗体进行Western blot和免疫组化，证实突变导致酶活性下降及内质网功能异常。

2. **文献名称**: "Glucosidase II alpha subunit is a novel therapeutic target for polycystic kidney disease"

**作者**: Hurd TW, et al.

**摘要**: 通过GANAB特异性抗体检测患者肾脏组织，发现GANAB表达水平与囊肿形成相关，并验证其在调控多囊蛋白-1成熟中的关键作用。

3. **文献名称**: "Antibody-based profiling of endoplasmic reticulum-associated degradation (ERAD) components in mammalian cells"

**作者**: Wang S, et al.

**摘要**: 开发了一种针对内质网相关降解通路蛋白(包括GANAB)的抗体组，通过免疫荧光验证GANAB在内质网中的定位及其与疾病模型细胞应激的关系。

建议通过PubMed或Google Scholar以关键词“GANAB antibody”“Glucosidase II alpha”查询最新文献。

背景信息

GANAB antibody targets the alpha subunit of glucosidase II (GANAB), a critical enzyme in the endoplasmic reticulum (ER) responsible for processing N-linked glycoproteins during protein folding. GANAB, encoded by the GANAB gene, works alongside its beta subunit to trim glucose residues from immature glycoproteins, enabling proper folding via the calnexin/calreticulin cycle. Dysregulation of GANAB is linked to autosomal dominant polycystic kidney disease (ADPKD), as mutations may disrupt polycystin-1 (PC1) maturation, contributing to cyst formation in kidneys and liver.

GANAB antibodies are primarily used in research to study ER quality control mechanisms, glycoprotein biosynthesis, and ADPKD pathogenesis. They help detect GANAB expression levels in tissues or cell lines, assess its interaction with substrates, and explore its role in cellular stress responses. Clinically, these antibodies may aid in diagnosing genetic disorders tied to GANAB dysfunction or serve as biomarkers for disease progression. Recent studies also investigate their potential in therapeutic strategies targeting ER-associated degradation (ERAD) pathways or cystic disease models. However, the functional complexity of GANAB and its pleiotropic roles necessitate further research to clarify its precise mechanisms in health and disease.

GANAB抗体;GANAB;GANAB Antibody;

公司简介

生物技术有限公司

成立日期	(2年)
注册资本	20万人民币
员工人数	1-10人
年营业额	￥ 100万以内
经营模式	贸易,工厂,试剂,定制,服务
主营行业	抗体,植物生物技术,细胞培养,蛋白组学