PRDX4抗体;PRDX4 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: MCF-7, K562, HepG2, 293T, Raji and Hela cell, Primary antibody: P12590(PRDX4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30S    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12590(PRDX4 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12590(PRDX4 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The PRDX4 (Peroxiredoxin 4) antibody is a crucial tool for studying the PRDX4 protein, a member of the peroxiredoxin family involved in cellular antioxidant defense. PRDX4 functions as a thiol-specific peroxidase, neutralizing reactive oxygen species (ROS) like hydrogen peroxide to protect cells from oxidative damage. Unlike other peroxiredoxins (PRDX1-6), PRDX4 is unique as a secreted protein, synthesized with a signal peptide that directs its transport to the endoplasmic reticulum (ER) and extracellular spaces. This secretory feature allows PRDX4 to regulate redox signaling both intracellularly and in extracellular environments, influencing processes such as protein folding, inflammation, and apoptosis.

PRDX4 antibodies are widely used in research to detect and quantify PRDX4 expression in tissues and cells via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate PRDX4's roles in diseases linked to oxidative stress, including cancer, neurodegenerative disorders (e.g., Alzheimer’s), diabetes, and cardiovascular conditions. For example, elevated PRDX4 levels in certain cancers correlate with tumor progression and drug resistance, while its deficiency is implicated in ER stress-related pathologies.

High-quality PRDX4 antibodies exhibit specificity for epitopes within conserved regions of the protein, ensuring minimal cross-reactivity with other PRDX isoforms. Researchers rely on these reagents to explore PRDX4's dual functions as an antioxidant and a redox-dependent signaling modulator, advancing therapeutic strategies targeting oxidative damage pathways.