SLC25A21抗体;SLC25A21 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12589(SLC25A21 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The SLC25A21 antibody is a research tool designed to detect and study the solute carrier family 25 member 21 (SLC25A21), a mitochondrial transporter protein. SLC25A21. also known as oxodicarboxylate carrier (ODC), facilitates the transport of α-ketoadipate and other dicarboxylates across the mitochondrial inner membrane, playing a role in amino acid catabolism and cellular energy metabolism. This antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate protein expression, localization, and function in various tissues and disease models.

Research involving SLC25A21 antibodies has highlighted its relevance in metabolic disorders, cancer, and mitochondrial dysfunction. For instance, altered SLC25A21 expression has been linked to impaired mitochondrial metabolism in certain cancers, suggesting potential diagnostic or therapeutic implications. Additionally, studies explore its role in rare genetic disorders affecting mitochondrial transport systems. Commercial SLC25A21 antibodies are typically raised in rabbits or mice using immunogenic peptide sequences specific to human or murine isoforms. Validation includes testing for specificity via knockout controls or siRNA knockdown. Researchers rely on these antibodies to advance understanding of mitochondrial transport mechanisms and their pathophysiological impacts.