GABRB1抗体;GABRB1 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12574(GABRB1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12574(GABRB1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The GABRB1 antibody is a research tool designed to target the β1 subunit of the gamma-aminobutyric acid type A (GABA-A) receptor, a major inhibitory neurotransmitter receptor in the central nervous system. GABA-A receptors are ligand-gated ion channels composed of various subunit combinations (e.g., α, β, γ), with the β1 subunit (encoded by the *GABRB1* gene) playing a critical role in receptor assembly, chloride ion channel function, and synaptic inhibition. Antibodies against GABRB1 are utilized to study receptor localization, expression levels, and structural interactions in neurological tissues or cell models.

Research involving GABRB1 antibodies has implications for understanding neurodevelopmental disorders, epilepsy, and anxiety-related conditions, as GABA-A receptor dysfunction is linked to these pathologies. For example, altered β1 subunit expression has been observed in certain epilepsy models and mood disorders. These antibodies are typically validated via techniques like Western blotting, immunohistochemistry, or immunofluorescence to ensure specificity. Challenges include cross-reactivity with other β subunits (β2. β3) due to structural homology, necessitating careful experimental controls. Commercially available GABRB1 antibodies support both basic research and potential diagnostic explorations, though their clinical application remains exploratory. Ongoing studies aim to clarify the subunit-specific mechanisms of GABA-A receptors in health and disease, highlighting the importance of reliable antibody tools.