HDAC5抗体;HDAC5 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P12565(HDAC5 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12565(HDAC5 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

Histone deacetylase 5 (HDAC5) is a class IIa enzyme within the HDAC family, which plays a critical role in regulating gene expression by removing acetyl groups from histones, leading to chromatin condensation and transcriptional repression. HDAC5 is involved in diverse cellular processes, including muscle differentiation, cardiac development, neuronal plasticity, and stress responses. It shuttles between the nucleus and cytoplasm, with its activity modulated by post-translational modifications, such as phosphorylation, which regulates its subcellular localization and interaction with transcription factors (e.g., MEF2. GATA) or co-repressors. Dysregulation of HDAC5 has been linked to diseases like cancer, neurodegenerative disorders, and cardiovascular pathologies.

HDAC5 antibodies are essential tools for studying its expression, localization, and molecular mechanisms. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to detect HDAC5 protein levels, assess its nuclear-cytoplasmic shuttling, or identify target genes. Specific antibodies can distinguish between phosphorylated (inactive, cytoplasmic) and unmodified (active, nuclear) forms, providing insights into signaling pathways (e.g., CaMK or PKD pathways) that regulate HDAC5. Researchers also utilize HDAC5 antibodies to explore its role in epigenetic therapies, as HDAC inhibitors are investigated for treating cancer and neurological diseases. Validation of antibody specificity via knockout controls or peptide blocking ensures reliable experimental outcomes in both basic and clinical research.