MORF4L1抗体;MORF4L1 Antibody—艾普蒂

The MORF4L1 (Mortality Factor 4 Like 1) antibody is a tool used to detect the MORF4L1 protein, a member of the MYST family of histone acetyltransferases. MORF4L1. also known as MRG15. plays a critical role in chromatin remodeling, transcriptional regulation, and DNA repair. It interacts with chromatin-modifying complexes, including the NuA4/TIP60 complex, to mediate histone H4 acetylation, influencing gene expression and genome stability. This protein is implicated in cellular processes such as cell cycle progression, apoptosis, and senescence, with links to aging and cancer. Dysregulation of MORF4L1 has been observed in various cancers, including breast and lung carcinomas, where it may act as an oncogene or tumor suppressor depending on context. Researchers use MORF4L1 antibodies in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study its expression, localization, and interactions in normal and diseased states. These antibodies are vital for exploring MORF4L1's role in epigenetic regulation and its potential as a therapeutic target or biomarker in age-related diseases and malignancies. Validation of antibody specificity is crucial, as MORF4L1 shares homology with other MRG family members like MORF4L2.