BAG2抗体;BAG2 Antibody—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Human fetal muscle tissue, HEPG2, Jurkat, Hela, A431 and A549 cell, Primary antibody: P12542(BAG2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12542(BAG2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12542(BAG2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The BAG2 (Bcl-2-associated athanogene 2) antibody is a tool used to study the BAG2 protein, a member of the BAG family of molecular chaperone regulators. BAG2 interacts with heat shock protein 70 (Hsp70) through its conserved BAG domain, modulating Hsp70’s ATPase activity to influence protein folding, degradation, and stress response pathways. Unlike other BAG family members, BAG2 uniquely lacks a ubiquitin-like domain and has been implicated in inhibiting CHIP (C-terminus of HSC70-interacting protein)-mediated ubiquitination of misfolded proteins, thereby delaying their proteasomal degradation. This function positions BAG2 as a critical player in protein quality control, particularly in neurodegenerative diseases like Alzheimer’s and Parkinson’s, where it may regulate tau and α-synuclein aggregation.

Research using BAG2 antibodies focuses on elucidating its role in cellular stress responses, cancer progression, and neurodegeneration. In cancer, BAG2 overexpression is linked to tumor cell survival and chemoresistance. In neurodegeneration, it may protect neurons by stabilizing misfolded proteins. The antibody is employed in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to detect BAG2 expression, localization, and protein interactions. Recent studies also explore its therapeutic potential as a target for modulating proteostasis. However, its dual roles in pro-survival and anti-degradation pathways necessitate context-specific analysis, highlighting the importance of reliable BAG2 antibodies in mechanistic studies.