FOXP4抗体;FOXP4 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell, Primary antibody: P12530(FOXP4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12530(FOXP4 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

FOXP4 is a member of the FOX (Forkhead box) protein family, characterized by a conserved forkhead DNA-binding domain. It functions as a transcription regulator involved in embryonic development, tissue differentiation, and cellular processes such as proliferation and apoptosis. FOXP4 is particularly notable for its role in lung development, neural system function, and immune regulation. Dysregulation of FOXP4 has been implicated in multiple diseases, including cancers (e.g., lung, ovarian, and hepatocellular carcinoma) and neurodevelopmental disorders. Studies suggest FOXP4 may act as both an oncogene and tumor suppressor, depending on context, highlighting its complex regulatory mechanisms.

FOXP4 antibodies are immunological tools designed to detect and quantify FOXP4 protein expression in research applications. These antibodies are essential for elucidating FOXP4's biological roles through techniques like Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. Validation of FOXP4 antibodies requires specificity testing via knockout controls or siRNA knockdown to avoid cross-reactivity with homologous family members (e.g., FOXP1. FOXP2). Recent research utilizing FOXP4 antibodies has uncovered its involvement in cancer progression, such as promoting epithelial-mesenchymal transition in tumors and modulating immune cell activity. Challenges in antibody development include ensuring consistent performance across species and tissue types. As interest grows in FOXP4's therapeutic potential, high-quality antibodies remain critical for advancing molecular studies and biomarker discovery.