FPR1抗体;FPR1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12529(FPR1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor (GPCR) belonging to the formyl peptide receptor family, primarily involved in innate immune responses. It is expressed on various immune cells, including neutrophils, monocytes, and macrophages, where it detects pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). FPR1 binds to formylated peptides, such as those released by bacteria during infection, initiating chemotaxis, phagocytosis, and inflammatory signaling. Its role extends beyond infection control; FPR1 is implicated in cancer progression, neuroinflammation, and autoimmune disorders due to its regulation of cell migration and cytokine release.

FPR1 antibodies are tools used to study receptor expression, localization, and function in both physiological and pathological contexts. They enable detection of FPR1 in tissues or cells via techniques like Western blot, immunohistochemistry, or flow cytometry. In research, these antibodies help elucidate mechanisms of FPR1-mediated signaling pathways, its interaction with ligands, and its cross-talk with other receptors. Therapeutic potential is also explored, as FPR1-targeting antibodies or inhibitors may modulate excessive inflammation or block tumor metastasis. However, challenges remain in specificity and off-target effects, necessitating careful validation. Overall, FPR1 antibodies are vital for advancing understanding of immune regulation and developing targeted therapies.