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  • ECM1抗体;ECM1 Antibody—艾普蒂
  • ECM1抗体;ECM1 Antibody—艾普蒂
  • ECM1抗体;ECM1 Antibody—艾普蒂

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ECM1抗体;ECM1 Antibody—艾普蒂

Rabbit Polyclonal ECM1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-26

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
ECM1抗体
英文名称：
Rabbit Polyclonal ECM1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6696 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
ECM1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesURBWD
WB Predicted band size61 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human ECM1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: LOVO and LO2 cell lysates, Primary antibody: P12521(ECM1 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12521(ECM1 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12521(ECM1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3篇关于ECM1抗体的文献摘要概述，供参考：

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1. **文献名称**: *ECM1 regulates tumor metastasis and chemoresistance via the YAP signaling*

**作者**: Wang X et al.

**摘要**: 研究揭示了ECM1在乳腺癌中通过激活YAP信号通路促进肿瘤转移和化疗耐药。使用抗ECM1抗体阻断其功能可显著抑制小鼠模型中肿瘤细胞的侵袭性，并增强化疗敏感性，提示ECM1抗体在靶向治疗中的潜力。

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2. **文献名称**: *Autoantibodies against ECM1 are linked to lipoid proteinosis pathogenesis*

**作者**: Hamada T et al.

**摘要**: 该研究首次在脂质蛋白沉积症患者血清中检测到针对ECM1的自身抗体，证实其与皮肤和黏膜异常沉积直接相关。抗ECM1抗体的发现为疾病诊断和机制研究提供了新方向。

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3. **文献名称**: *Targeting ECM1 in hepatocellular carcinoma with monoclonal antibody therapy*

**作者**: Li Y et al.

**摘要**: 开发了一种靶向ECM1的单克隆抗体，体外实验显示其可抑制肝癌细胞增殖并诱导凋亡。动物实验中，抗体治疗显著降低肿瘤负荷，表明ECM1是肝癌治疗的潜在分子靶点。

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**备注**：以上内容为模拟示例，实际文献需通过PubMed或Web of Science检索(关键词：ECM1 antibody/therapeutic)。如需具体文献，建议查询近年肿瘤学或免疫学领域期刊。

       

背景信息

The extracellular matrix protein 1 (ECM1) is a secreted glycoprotein encoded by the *ECM1* gene, first identified in 1997. It plays a multifaceted role in tissue development, angiogenesis, and cell differentiation by interacting with components of the extracellular matrix (ECM) and signaling pathways. ECM1 is expressed in various tissues, including skin, blood vessels, and bone, and exists in multiple isoforms (e.g., ECM1a, ECM1b) due to alternative splicing. Dysregulation of ECM1 has been implicated in pathological conditions such as cancer, autoimmune disorders, and skin diseases.

Antibodies targeting ECM1 have emerged as critical tools in research and diagnostics. In oncology, ECM1 overexpression correlates with tumor progression and metastasis in cancers like hepatocellular carcinoma and breast cancer, making ECM1 antibodies valuable for detecting tumor biomarkers. In dermatology, anti-ECM1 autoantibodies are linked to lichen sclerosus and lipoid proteinosis, aiding in disease diagnosis. Additionally, ECM1 antibodies are used to study the protein's role in angiogenesis, particularly its interaction with vascular endothelial growth factor (VEGF) pathways. Therapeutic applications are also being explored, including blocking ECM1 to inhibit tumor growth or modulate immune responses. However, challenges remain in understanding isoform-specific functions and optimizing antibody specificity for clinical use.

       
ECM1抗体;ECM1;ECM1 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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