SYNPO2抗体;SYNPO2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12258(SYNPO2 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12258(SYNPO2 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

SYNPO2 (synaptopodin-2), also known as myopodin, is a cytoskeleton-associated protein encoded by the *SYNPO2* gene. It plays critical roles in regulating actin dynamics, cell motility, and structural integrity, particularly in muscle cells and podocytes. The protein contains conserved actin-binding domains and is involved in cellular processes such as stress fiber formation, cell adhesion, and mechanotransduction. SYNPO2 has been implicated in cancer biology, where its expression is often downregulated in malignancies like prostate and bladder cancers, correlating with tumor progression, metastasis, and poor prognosis. It also interacts with tumor suppressors, such as PTEN, suggesting a role in oncogenic signaling pathways.

SYNPO2 antibodies are immunological tools designed to detect and quantify SYNPO2 protein expression in research applications. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study SYNPO2's localization, expression patterns, and functional roles in normal and diseased tissues. Commercially available SYNPO2 antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and validated for species reactivity (e.g., human, mouse, rat). Their utility extends to exploring SYNPO2's involvement in diseases like cancer, kidney disorders, and muscular pathologies, as well as its potential as a diagnostic or prognostic biomarker. Researchers rely on these antibodies to elucidate mechanisms underlying cytoskeletal remodeling, cell migration, and disease pathogenesis.