SRGAP2抗体;SRGAP2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12242(SRGAP2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

SRGAP2 (SLIT-ROBO Rho GTPase-activating protein 2) is a gene encoding a protein involved in neuronal development, particularly in cortical brain evolution and synaptic plasticity. It regulates cytoskeletal dynamics by interacting with the ROBO receptor and modulating Rho GTPase signaling, thereby influencing neuronal migration, dendritic spine maturation, and synapse formation. SRGAP2 is notable for its role in human-specific brain evolution; a human-specific partial duplication (SRGAP2C) is thought to have emerged ~2 million years ago, potentially contributing to enhanced cognitive functions by altering cortical neuron connectivity.

Antibodies targeting SRGAP2 are critical tools for studying its expression, localization, and function in neural tissues. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate SRGAP2's role in neurodevelopmental disorders (e.g., autism, schizophrenia) and evolutionary neurobiology. Studies using these antibodies have revealed SRGAP2's enrichment in pyramidal neurons and its involvement in regulating dendritic spine density. Recent research also explores SRGAP2C's antagonistic effects on ancestral SRGAP2. delaying spine maturation and promoting synaptic plasticity—a mechanism hypothesized to underlie human neocortical expansion. Validated SRGAP2 antibodies help dissect molecular pathways linking genetic changes to brain complexity and disease.