CCS抗体;CCS Antibody—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: P12230(CCS Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12230(CCS Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

**Background of CCS Antibodies**

CCS antibodies, often associated with autoimmune disorders, primarily refer to autoantibodies targeting cytoplasmic components implicated in specific clinical syndromes. A notable context is the anti-synthetase syndrome (ASS), where antibodies like anti-Jo-1. anti-PL-7. and anti-PL-12 recognize aminoacyl-tRNA synthetases—enzymes critical for protein synthesis. These antibodies are linked to a constellation of symptoms, including interstitial lung disease (ILD), myositis, arthritis, and Raynaud’s phenomenon. Their presence aids in diagnosing ASS and differentiating it from other connective tissue diseases.

Another context involves cytoplasmic staining patterns observed in indirect immunofluorescence (IIF), such as anti-mitochondrial antibodies (AMA) in primary biliary cholangitis or anti-ribosomal antibodies in systemic lupus erythematosus (SLE). CCS antibodies may also refer to novel or less-characterized autoantibodies targeting cytoplasmic antigens, which are increasingly identified through advanced techniques like immunoprecipitation or line immunoassays.

Clinically, CCS antibodies serve as biomarkers for disease stratification, prognosis, and therapeutic decisions. For example, anti-synthetase antibodies correlate with rapid ILD progression, guiding aggressive immunosuppression. Research continues to explore their pathogenic roles, including molecular mimicry or immune complex deposition. Detection methods, such as ELISA and immunoblotting, are vital for accurate diagnosis, underscoring their importance in autoimmune disease management.

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